Citrullus lanatus natural product library: A hoard of viable potential inhibitor candidates for diabetes mellitus type II therapeutic target enzymes

The ethnomedicinal function of several cucurbit species (cucumber, squash, melon, gourd, etc.) on diseases (i.e. diabetes, microbial infections, cancer, etc.), and as free radical scavengers have been reported. However, there remains infinitesimal record citron watermelon broad use, which reflects the reason for wide oversight underutilization, from lack recognition functional food crop development commercialization. objective this study focus towards identifying natural phytochemicals C. lanatus water melon molecules online database insilico computational approach to screened suitable antidiabetic lead, construction phylogenetic relatedness target Type 2 Diabetes Mellitus proteins was conducted predict reoccurrence analysis output with other homologous proteins. T2DM protein targets, phytochemical standard inhibitory drugs are mined different databases. Insilico docking analysis, adme/toxicity profiling virtually best fit. In additionally, relationship aligned targets confidence results compounds. Seventeen out nineteen potential drug candidates substantially passed test. Also, > 90% bootstrap likely produce a reoccurring result. Thus, these fulfil all enlisted criteria it is suggestively determined be potent drugs. It evident that Citrullus produced satisfactory output, reflect probable reservoir containing therapeutic discovery development. Additionally, derivatives can developed further effective screening